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STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

We provide unprecedented genetic and biochemical evidence that the antiapoptotic transcription factor STAT3 serves as a substrate for SYK tyrosine kinase both in vitro and in vivo. Induction of SYK in an ecdysone-inducible mammalian expression system results in STAT3 activation, as documented by tyr...

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Detalhes bibliográficos
Main Authors: Uckun, Fatih M., Qazi, Sanjive, Ma, Hong, Tuel-Ahlgren, Lisa, Ozer, Zahide
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840303/
https://ncbi.nlm.nih.gov/pubmed/20133729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909086107
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