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Involvement of Caspase Activation in Azaspiracid-Induced Neurotoxicity in Neocortical Neurons

Azaspiracids (AZAs) are a novel group of marine phycotoxins that have been associated with severe human intoxication. We found that AZA-1 exposure increased lactate dehydrogense (LDH) efflux in murine neocortical neurons. AZA-1 also produced nuclear condensation and stimulated caspase-3 activity wit...

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Autors principals: Cao, Zhengyu, LePage, Keith T., Frederick, Michael O., Nicolaou, Kyriacos C., Murray, Thomas F.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840215/
https://ncbi.nlm.nih.gov/pubmed/20047973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp312
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