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Brevetoxin-induced phosphorylation of Pyk2 and Src in murine neocortical neurons involves distinct signaling pathways

Brevetoxins (PbTx-1 to PbTx-10) are potent lipid soluble polyether neurotoxins produced by the marine dinoflagellate Karenia brevis. Brevetoxins bind to site 5 of the α-subunit of voltage-gated sodium channels (VGSCs) and augment Na(+) influx. In neocortical neurons brevetoxins elevate intracellular...

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Main Authors: Cao, Zhengyu, George, Joju, Baden, Daniel G., Murray, Thomas F.
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659874/
https://ncbi.nlm.nih.gov/pubmed/17963734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2007.09.065
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