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Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins

Cholera is a severe diarrheal disease caused by the motile Gram-negative rod Vibrio cholerae. Live-attenuated V. cholerae vaccines harboring deletions of the genes encoding cholera toxin have great promise for reducing the global burden of cholera. However, development of live vaccines has been hamp...

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Autors principals: Rui, Haopeng, Ritchie, Jennifer M., Bronson, Roderick T., Mekalanos, John J., Zhang, Yuanxing, Waldor, Matthew K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840140/
https://ncbi.nlm.nih.gov/pubmed/20160087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915164107
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