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Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8(+) T cells

To improve the efficacy of T cell–based vaccination, we pursued the principle that CD4(+) T cells provide help for functional CD8(+) T cell immunity. To do so, we administered HIV gag to mice successively as protein and DNA vaccines. To achieve strong CD4(+) T cell immunity, the protein vaccine was...

詳細記述

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書誌詳細
主要な著者: Nchinda, Godwin, Amadu, David, Trumpfheller, Christine, Mizenina, Olga, Überla, Klaus, Steinman, Ralph M.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840096/
https://ncbi.nlm.nih.gov/pubmed/20160099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000621107
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