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Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks

Caspase 3 is required for the differentiation of a wide variety of cell types, yet it remains unclear how this apoptotic protein could promote such a cell-fate decision. Caspase signals often result in the activation of the specific nuclease caspase-activated DNase (CAD), suggesting that cell differ...

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Bibliografische gegevens
Hoofdauteurs: Larsen, Brian D., Rampalli, Shravanti, Burns, Leanne E., Brunette, Steve, Dilworth, F. Jeffrey, Megeney, Lynn A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840077/
https://ncbi.nlm.nih.gov/pubmed/20160104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913089107
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