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Temporal activation of XRCC1-mediated DNA repair is essential for muscle differentiation

Transient DNA strand break formation has been identified as an effective means to enhance gene expression in living cells. In the muscle lineage, cell differentiation is contingent upon the induction of caspase-mediated DNA strand breaks, which act to establish the terminal gene expression program....

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Al-Khalaf, Mohammad H, Blake, Leanne E, Larsen, Brian D, Bell, Ryan A, Brunette, Steve, Parks, Robin J, Rudnicki, Michael A, McKinnon, Peter J, Jeffrey Dilworth, F, Megeney, Lynn A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860966/
https://ncbi.nlm.nih.gov/pubmed/27462438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.41
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