Blockade of MEK and MDM2 synergistically induces apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim

Molecular aberrations of the Ras/Raf/MEK/ERK and/or MDM2/p53 signaling pathways have been reported in 80% and 50% of primary AML samples and confer poor outcome. In this study, anti-leukemic effects of combined MEK inhibition by AZD6244 and non-genotoxic p53 activation by MDM2 antagonist Nutlin3a we...

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Hauptverfasser: Zhang, Weiguo, Konopleva, Marina, Burks, Jared K., Dywer, Karen C., Schober, Wendy D., Yang, Jer-Yen, McQueen, Teresa J., Hung, Mien-Chie, Andreeff, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840060/
https://ncbi.nlm.nih.gov/pubmed/20215498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0878
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