Role of BH3-Only Molecules Bim and Puma in β-Cell Death in Pdx1 Deficiency

Mutations in pancreatic duodenal homeobox-1 (PDX1) are associated with diabetes in humans. Pdx1-haploinsufficient mice develop diabetes due to an increase in β-cell death leading to reduced β-cell mass. For definition of the molecular link between Pdx1 deficiency and β-cell death, Pdx1-haploinsuffic...

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Hlavní autoři: Ren, Decheng, Sun, Juan, Wang, Changzheng, Ye, Honggang, Mao, Liqun, Cheng, Emily H., Bell, Graeme I., Polonsky, Kenneth S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2014
Témata:
Islet Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113059/
https://ncbi.nlm.nih.gov/pubmed/24658302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1513
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