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Safety and tolerability of putaminal AADC gene therapy for Parkinson disease
BACKGROUND: In Parkinson disease (PD), the benefit of levodopa therapy becomes less marked over time, perhaps because degeneration of nigrostrial neurons causes progressive loss of aromatic l-amino acid decarboxylase (AADC), the enzyme that converts levodopa into dopamine. In a primate model of PD,...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Academy of Neurology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2839805/ https://ncbi.nlm.nih.gov/pubmed/19828868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3181c29356 |
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