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Screening small-molecule compound microarrays for protein ligands without fluorescence labeling with a high-throughput scanning microscope

We describe a high-throughput scanning optical microscope for detecting small-molecule compound microarrays on functionalized glass slides. It is based on measurements of oblique-incidence reflectivity difference and employs a combination of a y-scan galvometer mirror and an x-scan translation stage...

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Detalhes bibliográficos
Main Authors: Fei, Yiyan, Landry, James P., Sun, Yungshin, Zhu, Xiangdong, Wang, Xiaobing, Luo, Juntao, Wu, Chun-Yi, Lam, Kit S.
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Photo-Optical Instrumentation Engineers 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839802/
https://ncbi.nlm.nih.gov/pubmed/20210464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1117/1.3309743
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