Amphiregulin Promotes Resistance to Gefitinib in NonSmall Cell Lung Cancer Cells by Regulating Ku70 Acetylation

Multiple molecular resistance mechanisms reduce the efficiency of receptor tyrosine kinase inhibitors such as gefitinib in non-small cell lung cancer (NSCLC). We previously demonstrated that amphiregulin (Areg) inhibits gefitinib-induced apoptosis in NSCLC cells by inactivating the proapoptotic prot...

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Bibliographic Details
Main Authors: Busser, Benoît, Sancey, Lucie, Josserand, Véronique, Niang, Carole, Khochbin, Saadi, Favrot, Marie C, Coll, Jean-Luc, Hurbin, Amandine
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839437/
https://ncbi.nlm.nih.gov/pubmed/19826407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.227
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