LEDGF Hybrids Efficiently Retarget Lentiviral Integration Into Heterochromatin

Correction of genetic diseases requires integration of the therapeutic gene copy into the genome of patient cells. Retroviruses are commonly used as delivery vehicles because of their precise integration mechanism, but their use has led to adverse events in which vector integration activated proto-o...

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Bibliographic Details
Main Authors:	Gijsbers, Rik, Ronen, Keshet, Vets, Sofie, Malani, Nirav, De Rijck, Jan, McNeely, Melissa, Bushman, Frederic D, Debyser, Zeger
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2010
Subjects:	Original Articles
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2839429/ https://ncbi.nlm.nih.gov/pubmed/20195265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.36
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LEDGF Hybrids Efficiently Retarget Lentiviral Integration Into Heterochromatin

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