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LEDGF Hybrids Efficiently Retarget Lentiviral Integration Into Heterochromatin

Correction of genetic diseases requires integration of the therapeutic gene copy into the genome of patient cells. Retroviruses are commonly used as delivery vehicles because of their precise integration mechanism, but their use has led to adverse events in which vector integration activated proto-o...

詳細記述

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書誌詳細
主要な著者: Gijsbers, Rik, Ronen, Keshet, Vets, Sofie, Malani, Nirav, De Rijck, Jan, McNeely, Melissa, Bushman, Frederic D, Debyser, Zeger
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839429/
https://ncbi.nlm.nih.gov/pubmed/20195265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.36
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