LEDGF Hybrids Efficiently Retarget Lentiviral Integration Into Heterochromatin

Correction of genetic diseases requires integration of the therapeutic gene copy into the genome of patient cells. Retroviruses are commonly used as delivery vehicles because of their precise integration mechanism, but their use has led to adverse events in which vector integration activated proto-o...

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Autores principales: Gijsbers, Rik, Ronen, Keshet, Vets, Sofie, Malani, Nirav, De Rijck, Jan, McNeely, Melissa, Bushman, Frederic D, Debyser, Zeger
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839429/
https://ncbi.nlm.nih.gov/pubmed/20195265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.36
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