Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD

Retrovirus-based vectors are commonly used as delivery vehicles to correct genetic diseases because of their ability to integrate new sequences stably. However, adverse events in which vector integration activates proto-oncogenes, leading to clonal expansion and leukemogenesis hamper their applicati...

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Detalhes bibliográficos
Main Authors: Vets, Sofie, De Rijck, Jan, Brendel, Christian, Grez, Manuel, Bushman, Frederic, Debyser, Zeger, Gijsbers, Rik
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615818/
https://ncbi.nlm.nih.gov/pubmed/23462964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.4
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