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Synthesis and In Vitro Evaluation of Taxol oxetane ring D precursors

A series of potential taxoid substrates was prepared in radiolabelled form to probe in vitro for the oxirane formation step and subsequent ring expansion step to the oxetane (ring D) presumably involved in the biosynthesis of the anticancer agent Taxol. None of the taxoid test substrates underwent t...

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Bibliografische gegevens
Hoofdauteurs: Kaspera, Rüdiger, Cape, Jonathan L., Faraldos, Juan A., Ketchum, Raymond E.B., Croteau, Rodney B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839165/
https://ncbi.nlm.nih.gov/pubmed/20305723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2010.02.033
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