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Synthesis and In Vitro Evaluation of Taxol oxetane ring D precursors

A series of potential taxoid substrates was prepared in radiolabelled form to probe in vitro for the oxirane formation step and subsequent ring expansion step to the oxetane (ring D) presumably involved in the biosynthesis of the anticancer agent Taxol. None of the taxoid test substrates underwent t...

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Bibliographic Details
Main Authors: Kaspera, Rüdiger, Cape, Jonathan L., Faraldos, Juan A., Ketchum, Raymond E.B., Croteau, Rodney B.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839165/
https://ncbi.nlm.nih.gov/pubmed/20305723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2010.02.033
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