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Synthesis and In Vitro Evaluation of Taxol oxetane ring D precursors
A series of potential taxoid substrates was prepared in radiolabelled form to probe in vitro for the oxirane formation step and subsequent ring expansion step to the oxetane (ring D) presumably involved in the biosynthesis of the anticancer agent Taxol. None of the taxoid test substrates underwent t...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2839165/ https://ncbi.nlm.nih.gov/pubmed/20305723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2010.02.033 |
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