Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis

DNAX adaptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in NK and myeloid cells. Absence of functional Dap12 results in osteoclast defects and bone abnormalities. Because DAP12 has no extracelluar binding domains, it must pair with cell surface recepto...

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Detalhes bibliográficos
Main Authors: Joyce-Shaikh, Barbara, Bigler, Michael E., Chao, Cheng-Chi, Murphy, Erin E., Blumenschein, Wendy M., Adamopoulos, Iannis E., Heyworth, Paul G., Antonenko, Svetlana, Bowman, Edward P., McClanahan, Terrill K., Phillips, Joseph H., Cua, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839155/
https://ncbi.nlm.nih.gov/pubmed/20212065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090516
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