Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma

In vitro differentiated CD8(+) T cells have been the primary focus of immunotherapy of cancer with little focus on CD4(+) T cells. Immunotherapy involving in vitro differentiated T cells given after lymphodepleting regimens significantly augments antitumor immunity in animals and human patients with...

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Main Authors: Xie, Ying, Akpinarli, Akgül, Maris, Charles, Hipkiss, Edward L., Lane, Malcolm, Kwon, Eun-Kyung M., Muranski, Pawel, Restifo, Nicholas P., Antony, Paul Andrew
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839147/
https://ncbi.nlm.nih.gov/pubmed/20156973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091921
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