NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice

BACKGROUND: Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective in generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent bacterial and fungal infections and by excessive inflammati...

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Bibliografiske detaljer
Main Authors: Segal, Brahm H., Han, Wei, Bushey, Jennifer J., Joo, Myungsoo, Bhatti, Zahida, Feminella, Joy, Dennis, Carly G., Vethanayagam, R. Robert, Yull, Fiona E., Capitano, Maegan, Wallace, Paul K., Minderman, Hans, Christman, John W., Sporn, Michael B., Chan, Jefferson, Vinh, Donald C., Holland, Steven M., Romani, Luigina R., Gaffen, Sarah L., Freeman, Michael L., Blackwell, Timothy S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838778/
https://ncbi.nlm.nih.gov/pubmed/20300512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009631
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