NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury

Recruitment of neutrophils and release of reactive oxygen species are considered to be major pathogenic components driving acute lung injury (ALI). However, NADPH oxidase, the major source of reactive oxygen species in activated phagocytes, can paradoxically limit inflammation and injury. We hypothe...

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Auteurs principaux: Davidson, Bruce A., Vethanayagam, R. Robert, Grimm, Melissa J., Mullan, Barbara A., Raghavendran, Krishnan, Blackwell, Timothy S., Freeman, Michael L., Ayyasamy, Vanniarajan, Singh, Keshav K., Sporn, Michael B., Itagaki, Kiyoshi, Hauser, Carl J., Knight, Paul R., Segal, Brahm H.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563868/
https://ncbi.nlm.nih.gov/pubmed/23296708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202410
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