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cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells

Kidney proton-secreting A-intercalated cells (A-IC) respond to systemic acidosis by accumulating the vacuolar ATPase (V-ATPase) in their apical membrane and by increasing the length and number of apical microvilli. We show here that the cell-permeant cAMP analog CPT-cAMP, infused in vivo, results in...

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Bibliografiske detaljer
Main Authors: Păunescu, Teodor G., Ljubojevic, Marija, Russo, Leileata M., Winter, Christian, McLaughlin, Margaret M., Wagner, Carsten A., Breton, Sylvie, Brown, Dennis
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838605/
https://ncbi.nlm.nih.gov/pubmed/20053793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00584.2009
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