CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress

We have recently shown that deletion of constitutively expressed CYP1B1 is associated with attenuation of retinal endothelial cell (EC) capillary morphogenesis (CM) in vitro and angiogenesis in vivo. This was largely caused by increased intracellular oxidative stress and increased production of thro...

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Bibliographic Details
Main Authors: Tang, Yixin, Scheef, Elizabeth A., Gurel, Zafer, Sorenson, Christine M., Jefcoate, Colin R., Sheibani, Nader
Format: Artigo
Language:Inglês
Published: American Physiological Society 2010
Subjects:
Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838582/
https://ncbi.nlm.nih.gov/pubmed/20032512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00153.2009
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