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Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA

Fragile X syndrome is caused by the loss of expression of the fragile X mental retardation protein, FMRP. FMRP is an RNA-binding protein that is highly expressed in neurons and undergoes multiple post-translational modifications including methylation on arginine. FMRP is methylated on the high-affin...

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Autors principals: Blackwell, Ernest, Zhang, Xing, Ceman, Stephanie
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838539/
https://ncbi.nlm.nih.gov/pubmed/20064924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq007
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