High-pressure liquid chromatography analysis and single-dose disposition of tobramycin in human volunteers.

A sensitive and specific fluorometric high-pressure liquid chromatography technique was developed to measure both tobramycin and an internal standard (gentamicin C2). The assay utilizes direct extraction of the o-phthalaldehyde derivatives from serum and urine. Coefficients of variation were 7.9% (s...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Haughey, D B, Janicke, D M, Adelman, M, Schentag, J J
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1980
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283846/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7396455/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.17.4.649
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