Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats.

The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days were compared in Fischer rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.

Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Parker, R A, Gilbert, D N, Houghton, D C, Porter, G A, Bennett, W M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1980
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283993/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7447411/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.18.2.346
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