Human S-Adenosylhomocysteine Hydrolase: Common Gene Sequence Variation and Functional Genomic Characterization

S-Adenosylhomocysteine hydrolase (AHCY) is the only mammalian enzyme known to catalyze the hydrolysis of S-adenosylhomocysteine (AdoHcy). We have used a genotype-to-phenotype strategy to study this important enzyme by resequencing AHCY in 240 DNA samples from four ethnic groups. Thirty-nine polymorp...

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Hauptverfasser: Feng, Qiping, Pelleymounter, Linda L., Moon, Irene, Kalari, Krishna R., Eckloff, Bruce W., Wieben, Eric D., Weinshilboum, Richard M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838417/
https://ncbi.nlm.nih.gov/pubmed/19619139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2009.06276.x
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