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Non-optimal microbial response to antibiotics underlies suppressive drug interactions
Antibiotics inhibiting translation can increase bacterial growth rate in the presence of DNA synthesis inhibitors. Here, we show that this extreme type of drug antagonism, termed suppression, results from non-optimal regulation of ribosomal genes, leading to sub-maximal growth in the presence of DNA...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2838386/ https://ncbi.nlm.nih.gov/pubmed/19914165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.10.025 |
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