The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling

Flaviviruses transmitted by arthropods represent a tremendous disease burden for humans, causing millions of infections annually. All vector-borne flaviviruses studied to date suppress host innate responses to infection by inhibiting alpha/beta interferon (IFN-α/β)-mediated JAK-STAT signal transduct...

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Detalhes bibliográficos
Main Authors: Laurent-Rolle, Maudry, Boer, Elena F., Lubick, Kirk J., Wolfinbarger, James B., Carmody, Aaron B., Rockx, Barry, Liu, Wenjun, Ashour, Joseph, Shupert, W. Lesley, Holbrook, Michael R., Barrett, Alan D., Mason, Peter W., Bloom, Marshall E., García-Sastre, Adolfo, Khromykh, Alexander A., Best, Sonja M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838099/
https://ncbi.nlm.nih.gov/pubmed/20106931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01161-09
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