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A common Gain of function of p53 cancer mutants in inducing genetic instability
The critical tumor suppressor p53 is mutated in over half of all human cancers. The majority of p53 cancer mutations are missense mutations, which can be classified into contact mutations that directly disrupt the DNA-binding motif of p53 but have modest impact on p53 conformation and structural mut...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2837937/ https://ncbi.nlm.nih.gov/pubmed/19881536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.376 |
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