Cyclic GMP/PKG-Dependent Inhibition of TRPC6 Channel Activity and Expression Negatively Regulates Cardiomyocyte NFAT Activation: Novel Mechanism of Cardiac Stress Modulation by PDE5 Inhibition

Increased cyclic GMP from enhanced synthesis or suppressed catabolism (e.g. PDE5 inhibition by sildenafil, SIL) activates protein kinase G (PKG) and blunts cardiac pathological hypertrophy. Suppressed calcineurin (Cn)-NFAT (nuclear factor of activated T-cells) signaling appears to be involved, thoug...

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Détails bibliographiques
Auteurs principaux: Koitabashi, Norimichi, Aiba, Takeshi, Hesketh, Geoffrey G., Rowell, Janelle, Zhang, Manling, Takimoto, Eiki, Tomaselli, Gordon F., Kass, David A.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837762/
https://ncbi.nlm.nih.gov/pubmed/19961855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.11.015
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