Hypoxia Promotes Glycogen Accumulation through Hypoxia Inducible Factor (HIF)-Mediated Induction of Glycogen Synthase 1

When oxygen becomes limiting, cells reduce mitochondrial respiration and increase ATP production through anaerobic fermentation of glucose. The Hypoxia Inducible Factors (HIFs) play a key role in this metabolic shift by regulating the transcription of key enzymes of glucose metabolism. Here we show...

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Main Authors: Pescador, Nuria, Villar, Diego, Cifuentes, Daniel, Garcia-Rocha, Mar, Ortiz-Barahona, Amaya, Vazquez, Silvia, Ordoñez, Angel, Cuevas, Yolanda, Saez-Morales, David, Garcia-Bermejo, Maria Laura, Landazuri, Manuel O., Guinovart, Joan, del Peso, Luis
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837373/
https://ncbi.nlm.nih.gov/pubmed/20300197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009644
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