Synthesis, Biophysical Properties and Pharmacokinetics of Ultrahigh Molecular Weight Tense and Relaxed State Polymerized Bovine Hemoglobins

Hemoglobin-based oxygen carriers (HBOC) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant commercial development, late stage clinical results of polymerized hemoglobin (PolyHb) solutions hamper development. We synthesized two types...

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Hlavní autoři: Buehler, Paul W., Zhou, Yipin, Cabrales, Pedro, Jia, Yiping, Sun, Guoyong, Harris, David R., Tsai, Amy, Intaglietta, Marcos, Palmer, Andre F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837140/
https://ncbi.nlm.nih.gov/pubmed/20149433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2010.01.072
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