Synthesis, Biophysical Properties and Pharmacokinetics of Ultrahigh Molecular Weight Tense and Relaxed State Polymerized Bovine Hemoglobins

Hemoglobin-based oxygen carriers (HBOC) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant commercial development, late stage clinical results of polymerized hemoglobin (PolyHb) solutions hamper development. We synthesized two types...

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Detalhes bibliográficos
Main Authors: Buehler, Paul W., Zhou, Yipin, Cabrales, Pedro, Jia, Yiping, Sun, Guoyong, Harris, David R., Tsai, Amy, Intaglietta, Marcos, Palmer, Andre F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837140/
https://ncbi.nlm.nih.gov/pubmed/20149433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2010.01.072
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