Th1 transcription factor T-bet regulates the expression of Tim-3

Tim-3 (T cell immunoglobulin, mucin domain)-3 is a membrane protein expressed at late stages of interferon-gamma secreting CD4(+) T helper type 1 (Th1) cell differentiation and constitutively on dendritic cells (DCs). Ligation of Tim-3 on Th1 cells terminates Th1 immune responses. In addition, Tim-3...

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Main Authors: Anderson, Ana C., Lord, Graham M., Dardalhon, Valerie, Lee, David H., Sabatos, Catherine A., Glimcher, Laurie H., Kuchroo, Vijay K.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837127/
https://ncbi.nlm.nih.gov/pubmed/20049876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939842
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