Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis

The activator of Hsp90 ATPase 1, Aha1, has been shown to participate in the Hsp90 chaperone cycle by stimulating the low intrinsic ATPase activity of Hsp90. To elucidate the structural basis for ATPase stimulation of human Hsp90 by human Aha1, we have developed novel mass spectrometry approaches tha...

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Main Authors: Koulov, Atanas V., LaPointe, Paul, Lu, Bingwen, Razvi, Abbas, Coppinger, Judith, Dong, Meng-Qiu, Matteson, Jeanne, Laister, Rob, Arrowsmith, Cheryl, Yates, John R., Balch, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836968/
https://ncbi.nlm.nih.gov/pubmed/20089831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-12-1017
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