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T-bet-/- RAG2-/- Ulcerative Colitis: the role of T-bet as a peacekeeper of host-commensal relationships
Inflammatory bowel disease is a disease that reflects a disequilibrium in host commensal homeostasis. T-bet-/- × RAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-α driven. Th...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2836906/ https://ncbi.nlm.nih.gov/pubmed/19666230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2009.07.007 |
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