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The transition state for peptide bond formation reveals the ribosome as a water trap
Recent progress in elucidating the peptide bond formation process on the ribosome has led to notion of a proton shuttle mechanism where the 2'-hydroxyl group of the P-site tRNA plays a key role in mediating proton transfer between the nucleophile and leaving group, whereas ribosomal groups do n...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2836634/ https://ncbi.nlm.nih.gov/pubmed/20080677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914192107 |
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