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Mechanistic alternatives for peptide bond formation on the ribosome

The peptidyl transfer reaction on the large ribosomal subunit depends on the protonation state of the amine nucleophile and exhibits a large kinetic solvent isotope effect (KSIE ∼8). In contrast, the related peptidyl-tRNA hydrolysis reaction involved in termination shows a KSIE of ∼4 and a pH-rate p...

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Publicado en:Nucleic Acids Res
Autores principales: Kazemi, Masoud, Sočan, Jaka, Himo, Fahmi, Åqvist, Johan
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009655/
https://ncbi.nlm.nih.gov/pubmed/29746669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky367
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