Synthesis, Radiolabeling and Biological Evaluation of (R)- and (S)-2-Amino-3-[(18)F]Fluoro-2-Methylpropanoic Acid (FAMP) and (R)- and (S)-3-[(18)F]Fluoro-2-Methyl-2-N-(Methylamino)propanoic Acid (NMeFAMP) as Potential PET Radioligands for Imaging Brain Tumors

The non-natural amino acids (R)- and (S)-2-amino-3-fluoro-2-methylpropanoic acid 5 and (R)- and (S)-3-fluoro-2-methyl-2-N-(methylamino)propanoic acid 8 were synthesized in shorter reaction sequences than in the original report starting from enantiomerically pure (S)- and (R)-α-methyl-serine, respect...

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Hlavní autoři: Yu, Weiping, McConathy, Jonathan, Williams, Larry, Camp, Vernon M., Malveaux, Eugene J., Zhang, Zhaobin, Olson, Jeffrey J., Goodman, Mark M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836592/
https://ncbi.nlm.nih.gov/pubmed/20028004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900556s
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