Intermonomer hydrogen bonds enhance GxxxG-driven dimerization of the BNIP3 transmembrane domain: roles for sequence context in helix-helix association in membranes

We determined the sequence dependence of human BNIP3 transmembrane domain dimerization using the biological assay TOXCAT. Mutants in which intermonomer hydrogen bonds between Ser 172 and His 173 are abolished show moderate interaction, indicating that side chain hydrogen bonds contribute to dimer st...

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Autores principales: Lawrie, Charles M., Sulistijo, Endah S., MacKenzie, Kevin R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836233/
https://ncbi.nlm.nih.gov/pubmed/20026130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.12.023
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