Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABA(A) receptors

Neuroactive steroids are potent modulators of γ-aminobutyric acid type A receptors (GABA(A)Rs), and their behavioral effects are generally viewed in terms of altered inhibitory synaptic transmission. Here we report that, at concentrations known to occur in vivo, neuroactive steroids specifically enh...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Stell, Brandon M., Brickley, Stephen G., Tang, C. Y., Farrant, Mark, Mody*, Istvan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283610/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14623958/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2435457100
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