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Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABA(A) receptors

Neuroactive steroids are potent modulators of γ-aminobutyric acid type A receptors (GABA(A)Rs), and their behavioral effects are generally viewed in terms of altered inhibitory synaptic transmission. Here we report that, at concentrations known to occur in vivo, neuroactive steroids specifically enh...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Stell, Brandon M., Brickley, Stephen G., Tang, C. Y., Farrant, Mark, Mody*, Istvan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283610/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14623958/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2435457100
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