SSeCKS/Gravin/AKAP12 Inhibits Cancer Cell Invasiveness and Chemotaxis by Suppressing a Protein Kinase C- Raf/MEK/ERK Pathway

SSeCKS/Gravin/AKAP12 (“SSeCKS”) encodes a cytoskeletal protein that regulates G(1) → S progression by scaffolding cyclins, protein kinase C (PKC) and PKA. SSeCKS is down-regulated in many tumor types including prostate, and when re-expressed in MAT-LyLu (MLL) prostate cancer cells, SSeCKS selectivel...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Su, Bing, Bu, Yahao, Engelberg, David, Gelman, Irwin H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836062/
https://ncbi.nlm.nih.gov/pubmed/20018890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.073494
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk