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ATPase Domain and Interdomain Linker Play a Key Role in Aggregation of Mitochondrial Hsp70 Chaperone Ssc1

The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. We have analyzed the interaction of Hep1 with mitochondrial Hsp70 (Ssc1) and the determinants in Ssc1 that make it prone to aggregation. The ATPase and peptide binding domain (PBD) of Hsp70 proteins are con...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Blamowska, Marta, Sichting, Martin, Mapa, Koyeli, Mokranjac, Dejana, Neupert, Walter, Hell, Kai
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836047/
https://ncbi.nlm.nih.gov/pubmed/20007714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.061697
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