Transforming Growth Factor β1 Inhibits Cystic Fibrosis Transmembrane Conductance Regulator-dependent cAMP-stimulated Alveolar Epithelial Fluid Transport via a Phosphatidylinositol 3-Kinase-dependent Mechanism

Exogenous or endogenous β(2)-adrenergic receptor agonists enhance alveolar epithelial fluid transport via a cAMP-dependent mechanism that protects the lungs from alveolar flooding in acute lung injury. However, impaired alveolar fluid clearance is present in most of the patients with acute lung inju...

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Main Authors: Roux, Jérémie, Carles, Michel, Koh, Hidefumi, Goolaerts, Arnaud, Ganter, Michael T., Chesebro, Brian B., Howard, Marybeth, Houseman, Benjamin T., Finkbeiner, Walter, Shokat, Kevan M., Paquet, Agnès C., Matthay, Michael A., Pittet, Jean-François
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836032/
https://ncbi.nlm.nih.gov/pubmed/19996317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036731
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