Murine cytomegalovirus paralyzes macrophages by blocking IFNγ-induced promoter assembly

Macrophages (Mϕ) are activated by IFNγ and are important cellular targets for infection by human and murine cytomegalovirus (MCMV), making it advantageous for CMVs to block IFNγ-induced Mϕ differentiation. We found that MCMV infection inhibited IFNγ regulation of many genes in Mϕ. MCMV infection blo...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Popkin, Daniel L., Watson, Mark A., Karaskov, Elizabeth, Dunn, Gavin P., Bremner, Rod, Virgin, Herbert W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283588/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14614150/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1835673100
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