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Murine cytomegalovirus paralyzes macrophages by blocking IFNγ-induced promoter assembly

Macrophages (Mϕ) are activated by IFNγ and are important cellular targets for infection by human and murine cytomegalovirus (MCMV), making it advantageous for CMVs to block IFNγ-induced Mϕ differentiation. We found that MCMV infection inhibited IFNγ regulation of many genes in Mϕ. MCMV infection blo...

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Detalhes bibliográficos
Main Authors: Popkin, Daniel L., Watson, Mark A., Karaskov, Elizabeth, Dunn, Gavin P., Bremner, Rod, Virgin , Herbert W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC283588/
https://ncbi.nlm.nih.gov/pubmed/14614150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1835673100
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