Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse

Annexin 7 (ANX7) acts as a tumor suppressor gene in prostate cancer, where loss of heterozygosity and reduction of ANX7 protein expression is associated with aggressive metastatic tumors. To investigate the mechanism by which this gene controls tumor development, we have developed an Anx7(+/-) knock...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Srivastava, Meera, Montagna, Cristina, Leighton, Ximena, Glasman, Mirta, Naga, Shanmugam, Eidelman, Ofer, Ried, Thomas, Pollard, Harvey B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283584/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14608035/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2235927100
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