Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/−) knockout mouse

The mammalian anx7 gene codes for a Ca(2+)-activated GTPase, which supports Ca(2+)/GTP-dependent secretion events and Ca(2+) channel activities in vitro and in vivo. To test whether anx7 might be involved in Ca(2+) signaling in secreting pancreatic β cells, we knocked out the anx7 gene in the mouse...

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Detalhes bibliográficos
Main Authors: Srivastava, Meera, Atwater, Illani, Glasman, Mirta, Leighton, Ximena, Goping, Gertrude, Caohuy, Hung, Miller, Georgina, Pichel, José, Westphal, Heiner, Mears, David, Rojas, Eduardo, Pollard, Harvey B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC24142/
https://ncbi.nlm.nih.gov/pubmed/10570150
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