Intracellular formation of ”undisruptable” dimers of inducible nitric oxide synthase

Overproduction of nitric oxide (NO) by inducible NO synthase (iNOS) has been implicated in the pathogenesis of many diseases. iNOS is active only as a homodimer. Dimerization of iNOS represents a potentially critical target for therapeutic intervention. In this study, we show that intracellular iNOS...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kolodziejski, Pawel J., Rashid, Mohammad B., Eissa, N. Tony
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283580/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14614131/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2435290100
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