Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

The availability of both the mouse and human genome sequences allows for the systematic discovery of human gene function through the use of the mouse as a model system. To accelerate the genetic determination of gene function, we have developed a sequence-tagged gene-trap library of >270,000 mous...

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Detalhes bibliográficos
Main Authors: Zambrowicz, Brian P., Abuin, Alejandro, Ramirez-Solis, Ramiro, Richter, Lizabeth J., Piggott, James, BeltrandelRio, Hector, Buxton, Eric C., Edwards, Joel, Finch, Rick A., Friddle, Carl J., Gupta, Anupma, Hansen, Gwenn, Hu, Yi, Huang, Wenhu, Jaing, Crystal, Key, Billie Wayne, Kipp, Peter, Kohlhauff, Buckley, Ma, Zhi-Qing, Markesich, Diane, Payne, Robert, Potter, David G., Qian, Ny, Shaw, Joseph, Schrick, Jeff, Shi, Zheng-Zheng, Sparks, Mary Jean, Van Sligtenhorst, Isaac, Vogel, Peter, Walke, Wade, Xu, Nianhua, Zhu, Qichao, Person, Christophe, Sands, Arthur T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC283554/
https://ncbi.nlm.nih.gov/pubmed/14610273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2336103100
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