Mutations in Growth Factor Independent-1 Associated with Human Neutropenia Block Murine Granulopoiesis through Colony Stimulating Factor-1

Severe congenital neutropenia (SCN) is characterized by a deficiency of mature neutrophils, leading to recurrent bacterial and fungal infections. Although mutations in Elastase-2, neutrophil (ELA2) predominate in human SCN, mutation of Ela2 in mice does not recapitulate SCN. The growth factor indepe...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Zarebski, Adrian, Velu, Chinavenmeni S., Baktula, Avinash M., Bourdeau, Tristan, Horman, Shane R., Basu, Sudeep, Bertolone, Salvatore J., Horwitz, Marshal, Hildeman, David A., Trent, John O., Grimes, H. Leighton
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835494/
https://ncbi.nlm.nih.gov/pubmed/18328744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.12.020
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi